Role of diffusion-weighted imaging and dynamic contrast enhanced magnetic resonance imaging in the diagnosis of early sacroiliitis in seronegative spondyloarthropathies, correlation with levels of acute phase reactants

Objective: Seronegative spondyloarthropathy (SpA) is a destructive disease. Early diagnosis crucial to prevent morbidity. Magnetic resonance imaging (MRI) the only modality that can show early sacroiliitis. We aimed investigate utility of dynamic contrast enhanced magnetic (DCE-MRI) and diffusion-weighted (DWI) in detection, quantification staging early/acute SpA. also investigated relationship between enhancement properties apparent diffusion coefficient (ADC) values with laboratory parameters for inflammation such as ESR CRP measurments. Patients Methods: Dynamic contrast-enhanced DWI were performed on 85 patients fulfilled criteria. A positive MRI finding was defined subchondral bone representing active Kinetic analyses performed, calculated, levels measured inflammation. Statistical performed. Results: In acute SpA group; quantity, area level enhancement, ADC Fenh, significantly higher than those chronic high agreement found threshold value 0.831x10 − 3 mm2/s according Assessment SpondyloArthritis International Society (ASAS) criteria (Kappa=0.794;p<0.001). Conclusion: are advanced MR techniques which enable They hallmarks Their combined use superior one alone